Primary Sclerosing Cholangitis (PSC)

Immune & Autoimmune

Overview
Symptoms
Diagnosis
Treatment
Research
Resources
Stories & Profiles

Overview

Primary sclerosing cholangitis is the inflammation and scarring of the bile ducts (tubes carrying bile) located inside and outside of the liver. Bile is digestive fluid that is transported from your liver to your small intestine through the bile ducts. PSC can cause the bile ducts to narrow and lead to build up of bile in the liver. This can cause progressive liver damage and over time in severe cases can lead to liver failure and need for liver transplant. It can also increase the risk of infection in bile duct, liver cancer, and bile duct cancer.

At A Glance

Digestive & Liver condition Causes inflammation

Common Signs And Symptoms

Fatigue
Itching
Pain In The Upper Abdomen
Sleep Disruptions And Night Sweats
Jaundice Yellowing Of Skin And Eyes
Fever And Chills

Symptoms may not occur for many people with PSC. However, some individuals may experience a variety of symptoms including:

Diagnosis Journey

Common tests used in diagnosis and monitoring of PSC:

Magnetic Resonance Cholangiopancreatography (MRCP)A MRCP is a special type of MRI that can be used to create detailed images of the liver and bile ducts.Liver Function Blood TestThis test checks the efficiency of your liver and liver enzyme levels.Endoscopic Retrograde Cholangiopancreatography (ERCP):This is an X-ray of the bile ducts and may be used in addition to an MRI. During an ERCP, a flexible tube is inserted down the throat and is used to inject dye into the area of connection between the bile duct and small intestine. An ERCP is used after an MRCP shows a blocked duct. An ERCP can also be performed to dilate and stent dominant strictures.Liver BiopsyA portion of the liver is removed and tested in a laboratory. This test is only used in special cases when the diagnosis is still uncertain.Additional ImagingImaging such as an ultrasound and CT scan can be done to screen for cancer. Fibroscans can also be done to follow and monitor degree of liver scarring/liver damage.

Treatment Options

Explore the treatment options available for PSC.

Treatments for Itching

There are no approved treatments for itching but some patients may find relief through the following options. Always speak with your doctor to determine what might be right for you.

01AntibioticsThe most common antibiotic to help relieve itching in PSC is called rifampin, which is a drug used to treat tuberculosis. Rifampin has been shown to relieve itching by activating receptors in a patient's gut and liver.
02Bile Acid SequestrantsCholestyramine is a common bile acid sequestrant that reduces high cholesterol and can improve itching in PSC.
03Ursodeoxycholic AcidThis medication can help relieve itching caused by liver disease by fighting bile acids that build up.

Ongoing Research

PSC is a rare disease and currently, there are no approved treatments by any regulatory agency.

Current Research Studies

There are over 275 primary sclerosing cholangitis clinical trials actively recruiting participants. Visit ClinicalTrials.gov to find PSC clinical trials near you.

Research & Resources

Clinical research helps scientists learn more about Primary Sclerosing Cholangitis (PSC) and develop better treatments for the future.